Endocrine Abstracts

Insulin and the IGFs, the IGFBPs and the insulin and IGF-1 receptors play an important role in cancer progression. Higher levels of circulating total IGF-1 is often associated with an increased risk of developing cancer. Furthermore, the IGF-1 receptor (IGF-1R) is often overexpressed in tumor tissues. This overexpression has been shown to be due to mutations in tumor suppressor genes such as p53, WT1 and BRCA genes. Inhibition of the IGF-1R in culture and preclinical studies l...